The latest studies have found that VEGFC specifically stimulates the expression of CXCR4 in lymphangiogenic endothelial cells and that VEGFD promotes breast cancer and cervical cancer cell adhesion, migration and metastasis through CXCR4 binding signals, while they have also shown that CXCR4 induces the expression of VEGFD through a feedback loop, indicating that the VEGFC/D/VEGFR3 axis and SDF1/CXCR4 axis might have several superimposed overlapping effects [22, 49]. This evidence concerns the gene CXCL12 and breast carcinoma.