Deletion of angiopoietin-1 from mice embryos coupled with injury or microvascular stress caused organ damage, accelerated angiogenesis and fibrosis, suggesting angiopoietin-1 may balance the angio-fibrogenic response associated with elevated VEGF-A and angiopoietin-2 levels from tissue injury and microvascular disease, like that observed in diabetes [18]. This evidence concerns the gene ANGPT2 and diabetes mellitus.