Resveratrol (RES) given orally for ten weeks reduced neural inflammation in a 6-OHDA-induced PD in rats, as was evidenced by suppression in the production of cyclooxygenase-2 (COX-2) and TNF-α in substantia nigra as well as ameliorating 6-OHDA-induced neurobehavioral deficit [30]. Here, PTGS2 is linked to Parkinson disease.