TP53 and neoplasm: The wt p53 revealed the inhibition of metastasis regulating target genes involved in key metastasis pathways, including EMT, ECM interactions, cell migration and anoikis [112] whereas the introduction of mutant p53s correlates with a more invasive tumor phenotype, suggesting that mutant forms of p53 not only lose their tumor suppressor properties, but also gain pro-metastatic functions, which stimulate increased migration and motility of tumor cells (Figure 1) [113,114].