In our study, JH was found to attenuate the destructive behaviors of RA-derived fibroblast-like synoviocyte MH7A cells through inhibiting proliferation, migration, and secretion of cytokines and MMPs including IL-1β, IL-6, IL-8, MMP-2, and MMP-3. This evidence concerns the gene CXCL8 and rheumatoid arthritis.