Moreover, c-MYC could be upregulated in MM cells by the autocrine or paracrine (BMSC-mediated) production of IL-6, which activates anti-apoptotic proteins, such as Myeloid cell leukemia 1 (Mcl1) and B-cell lymphoma-extra large (Bcl-XL), including c-MYC [8,70]. This evidence concerns the gene MYC and Miyoshi myopathy.