Cancer cells in a Tet-inducible transgenic mouse model of MYC-induced T cell acute lymphoblastic leukemia (MYC T-ALL) and of hepatocellular carcinoma (HCC) expressed both CD47 and PD-L1 when MYC was turned on and, oppositely, the knockdown of MYC in several cancer cell lines (T-ALL, HCC, melanoma, and non-small cell lung cancer) caused a reduction in their expression [71]. This evidence concerns the gene CD274 and cancer.