It was shown that the adhesion of MM to BMSCs increased miRNA-21 expression through the NF-κB pathway, since the treatment with BAY (an NF-κB specific inhibitor) or with bortezomib (that inhibits NF-κB pathway) prevented miRNA-21 upregulation in MM cells [95]. This evidence concerns the gene NFKB1 and Miyoshi myopathy.