BCL2 and Miyoshi myopathy: In MM miR-125a-5p was shown to downregulate the p53 pathway, since its expression in H929 cells induced a reduction of p53 mRNA and protein levels and of its downstream targets, such as cyclin-dependent kinase inhibitor 1A CDKN1A/p21, Bcl2 Associated X BAX, Growth Arrest And DNA-Damage-Inducible 45 Alpha (GADD45A), and Mouse Double Minutes 2 (MDM2).