ATF3 and neuroblastoma: PC12 and neuroblastoma SH-SY5Y cell lines were employed to discover the related mechanisms, which were related to the mitogen-activated protein kinase (MAPK), NF-kappa B, caspase 3 and 8 as well as reactive oxygen species (ROS)/activating transcription factor 3 (ATF3)/C/EBP-homologous protein (CHOP) pathways, as Figure 4 showed.