A further case of confirmed MDS-low risk with normal platelet count and increased bleeding tendency (recurring episodes over the previous 18 months), also showed defective GPVI-dependent aggregation (collagen, CRP), abnormally low GPVI surface expression on platelets and a signalling defect associated as a molecular abnormality in proteolytic processing of phosphorylated Syk [64]. This evidence concerns the gene CRP and myelodysplastic syndrome.