We observed decreased expression of EZH2 and BIRC3 transcripts upon knockdown of DARPP-32 (Supplementary Fig. 7a, b, c, d), whereas these NF-ĸB2 signaling targets increased upon overexpression of DARPP-32 or t-DARPP in NSCLC cells relative to controls (Supplementary Fig. 7e, f, g, h). This evidence concerns the gene PPP1R1B and non-small cell lung carcinoma.