To determine whether DARPP-32 isoforms regulate transcriptional effectors of non-canonical NF-ĸB2 signaling, we assessed the messenger RNA (mRNA) expression of EZH243 and BIRC344 transcriptional targets upon DARPP-32 isoform modulation in A549 and H1650 human NSCLC cells. The gene discussed is PPP1R1B; the disease is non-small cell lung carcinoma.