While 18F–FDG and 68Ga- or 18F–PSMA ligands will most probably remain the workhorses for oncologic hybrid imaging in the foreseeable future, several other imaging probes are being developed and clinically tested, which are intended to cover clinical scenarios in which 18F–FDG and PSMA ligands do not provide sufficient precision in tumor characterization. The gene discussed is FOLH1; the disease is neoplasm.