In the cell of the highly differentiated hepatocellular cancer, the glucose-6-phosphatase concentration is higher than in the unchanged hepatocyte, and the number of GLUT-2 molecules is reduced, which prevents glucose molecules from integrating into metabolic cascades in the volume required for imaging with 18F –FDG PET/CT (Argaud et al., 1997; Zeisel & Blusztajn, 1994; Ackerstaff et al., 2003). This evidence concerns the gene G6PC1 and hepatocellular carcinoma.