KLK3 and posterior cortical atrophy: Krause BJ et al. (Krause et al., 2008) reported 36% in patients presenting PSA serum level < 1 ng/mL after primary therapy for PCa, Nanni et al. (Nanni et al., 2013) reported 20% in radically treated patients and presenting PSA failure (>0.3 ng/mL), Giovacchini et al. (Giovacchini et al., 2010) reported 24% in patients radically treated and presenting PSA serum level < 1.4 ng/mL and 68% with PSA serum level > 1.4 ng/mL, Castellucci et al. (Castellucci et al., 2014) reported 28.4% in patients presenting early biochemical relapse (<2 ng/mL) after RP.