The deficiency in CXCL7 due to PKC phosphorylation leads to cAMP and CaMK II activation, subsequent Ca2+ release, and consequent osteoporosis and osteoclast reduction in spinal ligament tissues owing to the reduction of TRAF6-TAK1 transmission in obesity and diabetes. The gene discussed is PRRT2; the disease is obesity due to melanocortin 4 receptor deficiency.