In support of a potential effect of variable hormonal exposure on CLL progression, high expression of the androgen-inactivating UGT2B17 enzyme in peripheral blood mononuclear cells (PBMCs) of untreated CLL patients was associated with reduced treatment-free survival (TFS) and showed promise as a biomarker for IGHV-mutated CLL cases [18, 19]. The gene discussed is UGT2B17; the disease is B-cell chronic lymphocytic leukemia.