Similarly, some adults with SCD and early mild cognitive impairment (EMCI) show AD-related pathology, such as amyloid plaques, tau tangles, and cerebrospinal fluid (CSF) profiles that are similar to those observed in AD (decreased levels of amyloid and increased levels of total and phosphorylated tau; [19], [20], [21]). This evidence concerns the gene MAPT and Alzheimer disease.