PTGS2 and ocular melanoma: Inflammatory cytokines including TNF-α, cyclooxygenase-2 (COX-2), nuclear factor- (NF-) κB, interleukin- (IL-) 1, IL-6, and IL-8 play important roles in the initiation of mucosal changes, stimulation of mucin secretion, and immune regulation seen in OM [23–25].