ARID1A and ovarian clear cell cancer: In a similar study, Lakshminarasimhan and his colleagues discovered that the downregulation of ARID1A expression in an endometriosis cell line enhances colony formation capacity, cell adhesiveness, and invasiveness, suggesting that low ARID1A expression might be an early event in the malignant transformation of endometriosis to ovarian clear cell carcinoma (OCCC) [26].