RB1 and endometriosis: In a literature reported by Nie et al. [46], they investigated epigenetic modifications of hormones in endometriosis, and the results revealed that promoter of PRB was hypermethylated; additionally, treatment with both trichostatin A (TSA) and 5-aza-2'-deoxycytidine (ADC) increased PRB gene and protein expression in ectopic endometrial stromal cells but reduced cell viability of ectopic endometrial stromal cells.