A relevant study by Cacan [87] showed that loss of histone acetylation at RGS2 promoter genes results in the loss of RGS2 expression and indicated that the downregulation of the RGS2 gene is partly due to accumulation of HDACs at the promoter region of RGS2 in chemoresistant ovarian cancer cells. Here, RGS2 is linked to ovarian cancer.