Insulin itself can also undergo aggregation in its partially unfolded state.32–35In vitro studies proposed that the aggregation of insulin results in the deactivation of insulin as a regulator of glucose levels, therefore complicating the therapy for T2D.36 Similar to insulin, amylin plays a role in glucose homeostasis, but is found as aggregates in the pancreatic β-cells of type 2 diabetic patients. This evidence concerns the gene IAPP and type 2 diabetes mellitus.