For instance, two (upn08 and upn23) out of five AML cells highly sensitive to pomalidomide had low CRBN protein expression; the three other patients (upn07, upn18, and upn20) had blasts with high levels of CRBN protein, suggesting that the origin of pomalidomide sensitivity of these cells is unlikely due to a high expression of CRBN protein (Figure 6B). This evidence concerns the gene CRBN and acute myeloid leukemia.