Acting as an Extracellular Matrix Metalloproteinase Inducer as a main role, CD147 is thus also referred to as “EMMPRIN.” Once matrix metalloproteinases (such as MMP1, MMP2, and MMP11) are induced by CD147, the enzymes help to break the extracellular matrix thus aiding in the proliferation of tumor cells (101–103). This evidence concerns the gene BSG and neoplasm.