Oncolytic vesicular stomatitis virus expressing IFN-γ demonstrated greater activation of DCs, higher pro-inflammatory cytokines’ secretion, and reduced tumor growth in 4T1 tumor model compared with the parental virus, suggesting that specific production of the IFN-γ within the tumor microenvironment is beneficial for the antitumor immune response (302). This evidence concerns the gene IFNG and neoplasm.