Indeed, Th1-secreted IFN-γ was shown to trigger a cytotoxic activity of tumor-associated macrophages (TAMs) and also induces CXCL9/MIG and CXCL10/IP-10 secretion by macrophages, which may affect the tumor progression by angiogenesis inhibition (129). Here, CXCL10 is linked to neoplasm.