KCa3.1 is considered a therapeutic target in the CNS because selective KCa3.1 blockers have improved the outcome in animal models of trauma, spinal cord injury, stroke and neurodegeneration (reviewed in Maezawa et al., 2012; Feske et al., 2015; Chen et al., 2016; Dale et al., 2016). The gene discussed is KCNN4; the disease is Stroke.