EGFR and lung adenocarcinoma: The H1975 cell line is derived from a human lung adenocarcinoma and has the oncogenic EGFR tyrosine kinase activating mutation L858R as well as the T790M mutation that makes it resistant to first-generation EGFR tyrosine kinase inhibitors (TKIs) such as gefitinib and erlotinib (Kobayashi et al., 2005; Kwak et al., 2005; Pao et al., 2005).