MC4R and type 2 diabetes mellitus: More recently, the largest European ancestry-focused GWAS of T2D, which tested 27 million variants and included more than 74,000 cases showed that 26 of the more than 400 conditionally independent variants at the identified loci for T2D predominantly increase risk through their effect on BMI, including established adiposity loci such as FTO, MC4R and TMEM18 [24••].