These miRNAs were thus able to target key genes involved in these pathways and in cancer development such as TP53, APC, several proteins of the WNT family (WNT3A,WNT5A and WNT9A) and of the MAPK family (MAPK1, MAPK8 and MAPK9), VEGFA and MYC suggesting their possible use in diagnostic and clinical practice. The gene discussed is APC; the disease is cancer.