SLC1A2 and amyotrophic lateral sclerosis: An in vitro study demonstrated that 4-HNE impairs the glutamate and glucose transport and the choline acetyltransferase activity in cultured motor neurons [199], while human autopsy materials have shown increased levels of 4-HNE, which modifies astrocytic glutamate transporter EAAT2 (excitatory amino acid transporter 2) impairing glutamate transport in ALS.