Neuroligin‐1 is present in excitatory synapses, neuroligin‐2 in inhibitory synapses, Neuroligin‐3 (NLGN3) in both excitatory and inhibitory synapses, and neuroligin‐4 in glycinergic synapses.14, 15 Mostly, NLGN3 point mutation is associated with autism.16, 17, 18 Recent studies have shown that NLGN3 plays an important role in brain tumors, and the microenvironmental NLGN3 is necessary for glioma growth. This evidence concerns the gene NLGN3 and central nervous system cancer.