Previous studies have shown that NLGN3 promotes the proliferation of gliomas by activating the PI3K‐mTOR pathway.20 Therefore, we further tested the level of p‐AKT (S473) in the GBM tissue and found that the level of p‐AKT (S473) was higher in the fundus region (Figure 3K,L). The gene discussed is NLGN3; the disease is central nervous system cancer.