LGR5, which belongs to the G protein‐coupled receptor family of proteins, is recognized as a stem cell marker of the intestinal epithelium and the hair follicle 6, 7, and has been identified as an oncogene in various cancers, including colorectal cancer 24, cervical cancer 25, neuroblastoma 26, and ovarian cancer 9. The gene discussed is LGR5; the disease is cancer.