BCL2 and cancer: Lipopeptides have been found to kill many types of cancer cells by inhibiting ERK1/2 and Akt activation, causing ROS burst, cell-cycle arrest, enhancing the bax-to-bcl-2 expression ratio, and caspase activation (Cao et al. 2010; Hajare et al. 2013; Kim et al. 2007; Yin et al. 2013).