Female gender was not associated with increased risk of depression after adjustment for potential confounding factors such as age, insulin use, HbA1c, smoking status, medication adherence, diet difficulty, physical activity, glucose monitoring, use of antidepressant medications or counselling, own health rating and diabetes distress score [0.96 (0.77–1.18), p = 0.672]. This evidence concerns the gene INS and depressive disorder.