Factors associated with diabetes distress among women and men with type 2 diabetes slightly differed with a greater number among women (younger age, insulin use, higher HbA1c, requirement for interpreter, diet difficulty, being unsure of glucose monitoring recommendations, likely depression and lower own health rating) than among men (higher HbA1c, diet difficulty, likely depression and lower own health rating) (data not shown). The gene discussed is INS; the disease is major depressive disorder.