TF and glioblastoma: Studies have shown therapeutic efficacy using daunorubicin-loaded liposomes functionalized with transferrin and p-aminophenyl-α-d-manno-pyranoside in C6 rat intracranial orthotopic tumors24, or transferrin modified cyclo-[Arg-Gly-Asp-d-Phe-Lys]-paclitaxel conjugate loaded micelles25 and doxorubicin-loaded liposomes dual functionalized with a D-peptide ligand of the acetylcholine receptor and cyclic-[Arg-Gly-Asp] peptide26 in U87MG intracranial orthotopic tumors, however, neither daunorubicin, paclitaxel, nor doxorubicin are first-line therapies for GBM.