TNF-targeted biological therapy with monoclonal antibodies (infliximab, adalimumab, golimumab, certolizumab pegol) or soluble receptors (etanercept) dramatically changed the course of several chronic inflammatory diseases such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis, psoriasis (PsO), and inflammatory bowel disease (IBD)2. The gene discussed is TNF; the disease is inflammatory bowel disease.