The main tenets of how tumor-induced “wounds” form are as follows: (1) VEGFa promotes angiogenesis and increased vascular permeability, (2) this in turn leads to extravasation of fibrinogen and several classes of lymphocytes, (3) activation of the coagulation cascade occurs, (4) fibrin deposition takes place, and (5) an irregular collagen matrix forms. This evidence concerns the gene VEGFA and neoplasm.