Moreover, a positive correlation between lncPARP1 and PARP1 expression in HCC tissues was observed, suggesting that PARP1 was a bona fide target gene of lncPARP1. Unfortunately, we did not reveal the exact mechanism of PARP1 expression induced by lncPARP1. Previous studies demonstrated that intergenic lncRNAs exert functions through interaction with epigenetic modifier to regulate nearby protein-coding gene expression [25]. The gene discussed is PARP1; the disease is hepatocellular carcinoma.