PCSK9 and deep vein thrombosis: For example, higher plasma levels of low-density lipoproteins (LDL) likely enhance leukocyte accumulation since deficiency in proprotein convertase subtilisin/kexin type 9 (PCSK9), an enzymatically inactive protein that binds the LDL receptor favoring its degradation, significantly reduces leukocyte adhesion and thrombus growth in the stenosis DVT model [57].