Encouragingly, transgenic overexpression of Cyclin A2 (CCNA2) in murine cardiac myocytes results in an increase in the number of proliferating cell nuclear antigen-positive or phospho-histone H3+ cells in the heart, and adenoviral delivery of Cyclin A2 after myocardial infarction in pigs produces increased myocyte mitoses and improved function (reviewed in [6]). This evidence concerns the gene CCNA2 and myocardial infarction.