Moreover, we also compared the expression of β-MHC, which is upregulated in cardiac hypertrophy, and found that FGF-2 (25 ng/mL for 48 h)-induced β-MHC mRNA upregulation was significantly attenuated in calcitriol (10 nM)-treated HL-1 cells (Fig. 2b). The gene discussed is FGF2; the disease is cardiac hypertrophy.