ADAM17 and neoplasm: Further analysis showed a significant correlation between ADAM-10 overexpression and T stage (P = 0.009) and AJCC TNM stage (P = 0.007), ADAM-17 and larger tumor size (P = 0.007) and AJCC TNM stage (P = 0.002), ADAM-28 and AJCC TNM stage (P = 0.027) (Table 1).