Aberrant epigenetics were suggested to be responsible for intrinsic Wnt pathway activation in MM cells by Chim et al., who analyzed DNA methylation of CpG islands, indicative of transcriptional repression and subsequent gene silencing, in the promoter regions of the Wnt antagonists WIF1, Dkk3, APC and sFRP1, sFRP2, sFRP4, and sFRP5. The gene discussed is SFRP2; the disease is Miyoshi myopathy.