MAPT and proteostasis deficiencies: We crossed the G85R-SOD1:YFP mice to three different models of proteinopathies: 1) a model of spinal tau pathology expressing human P301L tau (termed JNPL3 [47]), 2) a model of spinal αSyn pathology expressing human A53T αSyn (termed M83 [48]), and 3) a model of cortical tau pathology expressing human P301L tau (termed rTg4510 [49, 50]).