Hemizygous mice expressing G85R-SOD1:YFP do not intrinsically develop ALS symptoms or show inclusion pathology, while homozygous G85R-SOD1:YFP mice develop paralysis from 6 months onward with spinal cords that contain fluorescent inclusions and detergent-insoluble G85R-SOD1:YFP [46]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.