Recent transcriptomic studies of mouse models of tauopathy, including the JNPL3 and rTg4510, and transcriptomic studies of human tauopathies (Alzheimer’s Disease [AD] and progressive supranuclear palsy [PSP]), however, have demonstrated that SOD1 expression is not induced in any of these disease settings (Additional file 11; Table S1). This evidence concerns the gene SOD1 and Classical progressive supranuclear palsy.