While RNAi of a single gene (e.g. ATP6AP1, COPA, or ARCN1) inhibited replication of many strains of influenza tested here, there were several endemic strains that were not inhibited, and inhibition of diverse strains (e.g. H7N3, H9N2) was particularly weak in the absence of combinatorial RNAi. The gene discussed is ATP6AP1; the disease is influenza.