These results will also necessitate a reappraisal of the mechanisms and role of astrocytes in potassium accumulation during seizure activity [61], especially given the observation that loss of function mutations in the gene encoding Kir4.1 are associated with a human epilepsy syndrome [62] and astrocyte Kir4.1 expression is decreased in acquired epilepsy models [63]. The gene discussed is KCNJ10; the disease is epilepsy syndrome.