Fasting serum glucose was significantly lower in the F0 HF/HS—F1 Chow group than all other groups (Fig 2G) while mice fed a HF/HS diet post-weaning had higher fasting insulin levels and this was statistically significant in the F0 HF/HS—F1 HF/HS cohort (Fig 2H). This evidence concerns the gene INS and hydrops fetalis.