Many researches have explored the role of TLR2 and TLR4 in the induction of host immunity against major parasitic diseases such as leishmaniasis [40], malaria [41], trypanosomiasis [42], filariasis [43] and schistosomiasis [44].These researches reveal that stimulation of host immune response with TLR2 and TLR4 agonist can be the option of choice to treat such parasitic diseases in future. The gene discussed is TLR4; the disease is schistosomiasis.