TLR4 and trypanosomiasis: Many researches have explored the role of TLR2 and TLR4 in the induction of host immunity against major parasitic diseases such as leishmaniasis [40], malaria [41], trypanosomiasis [42], filariasis [43] and schistosomiasis [44].These researches reveal that stimulation of host immune response with TLR2 and TLR4 agonist can be the option of choice to treat such parasitic diseases in future.