R-Ras also attenuates ECs’ response to VEGF by inhibiting VEGF receptor 2 (VEGFR2) internalization or autophosphorylation, including the Tyr 951 phosphorylation (Tyr 949 in mouse) that is implicated in the tumor vascular permeability to permit metastatic tumor spreading (4, –6). The gene discussed is RRAS; the disease is neoplasm.