By univariable analysis (Table 2), the factors significantly associated with the occurrence of severe NE were nephrotoxic drug intake, visual disorders, hematuria, leukocyte count >10 × 109 cells/L, C-reactive protein >100 mg/L (>952 nmol/L), and thrombocytopenia <90 × 109/L. This evidence concerns the gene CRP and Hematuria.