It has been reported that the ratio of 4-repeat Tau (4R-Tau)/3-repeat Tau (3R-Tau) is high in tauopathies, including FTLD, progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD) (Hong et al., 1998; Yoshida, 2006; Umeda et al., 2013). This evidence concerns the gene MAPT and tauopathy.