It has been reported that FUS binds U-rich small nuclear ribonucleoproteins (snRNPs) and the SMN cmplex, which is the machinery for snRNP biogenesis, and hence compromises precursor mRNA splicing, leading to FUS-associated FTLD/ALS (Tsuiji et al., 2013; Sun et al., 2015). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.