We then became interested if the regulation by hypoxia would occur in patients suffering hypoxemic diseases and whether the remodeling of AQP1 expression may play a role in developing pathologies, such as chronic obstructive pulmonary disease (EPOC) (Calero et al., 2014) and IPF (Gutiérrez et al., 2013). Here, AQP1 is linked to idiopathic pulmonary fibrosis.