Moreover, in a murine model of acute lung injury a relationship between ANGII and AQP1 expression was indicated (Cao et al., 2010) and up-regulation of pulmonary AQP1 expression was observed in mice with pulmonary fibrosis induced by bleomycin (Gao et al., 2013), leading authors to propose a possible role for AQP1 in the pathogenesis of lung fibrosis. This evidence concerns the gene AGT and pulmonary fibrosis.