In the case of brachyury-mediated mesenchymalization of human carcinoma cells, the mechanism of immune resistance was identified as a defect in the phosphorylation and subsequent cleavage of the nuclear lamins during apoptosis, a defect caused by the loss of the cell-cycle dependent kinase-1 (CDK1), due to decreased protein stability (17). The gene discussed is TBX1; the disease is carcinoma.