Detailed molecular analysis of GBM reveals dysregulation of core signaling pathways including those that regulate cell growth, DNA repair and apoptosis like receptor tyrosine kinase (RTK), phosphoinositide 3-kinase (PI3K) signaling, mitogen activated protein kinase (MAPK) signaling, retinoblastoma and p53 signaling [9]. This evidence concerns the gene TP53 and glioblastoma.